Brian K. Vaughan won the Eisner Award for Best Writer 4 times (2005, 2013, 2014, 2017).
| Year | Contest | Category | For | Sources |
|---|---|---|---|---|
| 2017 | Eisner Award | Best Writer | Paper Girls | 1 · 2 |
| 2014 | Eisner Award | Best Writer | Saga | 1 · 2 |
| 2013 | Eisner Award | Best Writer | Saga | 1 · 2 |
| 2005 | Eisner Award | Best Writer | Y: The Last Man | 1 · 2 |