Edie Falco won the Primetime Emmy Awards for Outstanding Lead Actress in a Drama Series three times (1999, 2001, 2003). Edie Falco won the Primetime Emmy Awards for Outstanding Lead Actress in a Comedy Series in 2010 for Nurse Jackie.
| Year | Contest | Category | For | Sources |
|---|---|---|---|---|
| 2010 | Primetime Emmy Awards | Outstanding Lead Actress in a Comedy Series | Nurse Jackie | 1 · 2 |
| 2003 | Primetime Emmy Awards | Outstanding Lead Actress in a Drama Series | The Sopranos | 1 · 2 |
| 2001 | Primetime Emmy Awards | Outstanding Lead Actress in a Drama Series | The Sopranos | 1 · 2 |
| 1999 | Primetime Emmy Awards | Outstanding Lead Actress in a Drama Series | The Sopranos | 1 · 2 |